Following the Viscontis, in 1450 a new dynasty, represented by Francesco Sforza, began to rule in Milan (until 1535). Francesco was the first to have his portrait struck on gold and silver coins. His successor, Galeazzo, did the same.

On behalf of the latter's son, Gian Galeazzo Maria Sforza, his uncle, Ludovico Maria Sforza, called "Il Moro", managed affairs of state. The latter was the important patron of Renaissance art in Milan.

At his invitation, personalities like Bramante (who later drew up the plans for the reconstruction of St Peter's in Rome) remained in the city from 1480 and Leonardo da Vinci from 1483 and gave the art scene the decisive Renaissance impetus. The portraits on the gold and silver coins of Milan under Ludovico il Moro's regency and later rule are among the most perfect Renaissance works of art.